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PetPals
Real discussions from product enthusiasts
User Reports of Flea Resistance to FRONTLINE Plus
Some dog owners in specific regions are reporting that FRONTLINE Plus is no longer effective against fleas, leading them to switch to alternative treatments. This suggests potential localized resistance to the fipronil active ingredient.
Application Speed and Neurological Side Effects Reported
Discussions indicate FRONTLINE Plus takes 24-48 hours to kill fleas and some users have observed temporary neurological side effects like head wobbling shortly after application. Proper application directly to the skin is emphasized for absorption.
Importance of Correct Application for Absorption
To maximize the effectiveness of FRONTLINE Plus, users emphasize applying it directly to the skin by parting the fur, typically between the shoulder blades. This ensures proper absorption into the skin's oils for widespread protection.
Mixed Views on FRONTLINE Plus Long-Term Efficacy
While many pet owners find FRONTLINE Plus highly effective for consistent, long-term flea and tick control over months, others have experienced a decline in effectiveness, prompting a search for newer formulations or different brands.
Expert answers based on real user experience
FRONTLINE Plus is designed to start killing fleas within 24 to 48 hours of application, according to user reports and product information. This topical treatment targets adult fleas, as well as flea eggs and larvae, by disrupting their development and killing existing adult parasites. For ticks, efficacy begins within 48 hours. Consistent monthly application is key to breaking the flea life cycle, as it prevents new infestations from establishing by eliminating developing stages. The fipronil active ingredient works by affecting the insect's nervous system, while (S)-methoprene acts as an insect growth regulator.
r/DogAdvice, Product Information
User feedback on FRONTLINE Plus effectiveness is varied. Many small dog owners report successful flea and tick elimination for several consecutive months with consistent monthly applications. However, some communities note that fleas in certain geographic areas may have developed resistance to fipronil, prompting owners to seek alternative treatments like Nexgard or Simparica. While the product is generally trusted, occasional reports suggest it may not be fully effective in all situations, particularly if flea populations exhibit regional resistance or if application protocols are not strictly followed.
Frontline
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Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog's entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.
| UPC | 010756261365 350604287001 |
| ASIN | B00008DFGY |
| GTIN | 010756261365 350604287001 |
| Brand | Frontline |
| Scent | Orange |
| Volume | 264.5 Milliliters |
| Item Form | Liquid |
| Brand Name | Frontline |
| Department | Flea & Tick |
| Scent Name | Orange |
| Unit Count | 3 Count |
| Item Volume | 264.5 Milliliters |
| Item Weight | 0.01 Pounds |
| Manufacturer | Boehringer Ingelheim Animal Health |
| Model Number | 74273 |
| Dog Breed Size | Small |
| Item Type Name |
-9%Frontline
FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
-9%Frontline
FRONTLINE Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments
FRONTLINE
FrontLine Povidone Iodine Swabs, 10% More Iodine Antiseptic Solution, Cotton Swabsticks for Wound Care, Nasal Cleansing, First Aid & Medical Supplies, Individually Wrapped Box of 50
r/dogs, r/pets
While FRONTLINE Plus is generally considered safe when used as directed and is trusted by pet owners for over 20 years, some users have reported adverse reactions. These can include temporary neurological symptoms such as disorientation or head wobbling shortly after application, though such instances are not widespread. Accidental ingestion, as reported in one case with a cat, can lead to drooling but is typically managed as the product is formulated to be non-toxic. It is crucial to apply the liquid directly to the skin, at the base of the skull, to minimize ingestion risks and ensure proper absorption.
r/dogs, r/DogAdvice, r/pets
To ensure FRONTLINE Plus is applied effectively, part your dog's fur at the specific spot between the shoulder blades, directly on the skin. Apply the entire contents of the applicator tube evenly to this single spot. This direct-to-skin application, rather than to the fur, is vital for the product to be absorbed into the oils of the skin and then spread across the body surface, providing a protective barrier. Avoid applying to areas where the dog can lick it off. For optimal results, do not bathe your dog for at least 48 hours before or after application, as this can affect the product's distribution and efficacy.
r/DogAdvice, Product Information
While some users debate pre-application bathing, the general recommendation and product guidelines suggest avoiding bathing with harsh flea or tick shampoos for at least 48 hours before and after applying FRONTLINE Plus. These shampoos can strip the natural oils from the skin and coat, which are key for the proper absorption and distribution of the topical treatment across the dog's body. The active ingredients in FRONTLINE Plus, fipronil and (S)-methoprene, rely on these oils to spread effectively. Using gentler, oatmeal-based shampoos, as some users suggest, might be less disruptive, but it's generally best to let the topical treatment work without immediate interference from other bathing products.
r/dogs, r/DogAdvice, Product Guidelines
Newer formulations such as FRONTLINE Gold and FRONTLINE Shield are generally considered to offer enhanced protection compared to the original FRONTLINE Plus. While the original formula effectively targets adult fleas, eggs, and larvae, and kills ticks, newer versions often incorporate additional active ingredients or improved delivery mechanisms. For instance, FRONTLINE Gold includes an insect growth inhibitor (IGR) for extended protection against immature flea stages. These advancements aim to combat potential resistance and provide a broader spectrum of control against a wider range of parasites or for longer durations, though specific comparative efficacy data between formulations can vary.
r/dogs, Product Comparisons
| Flea and Tick Treatment for Dogs Small Dogs |
| Target Species | Dog |
| Customer Reviews | 4.4 4.4 out of 5 stars (48,666) 4.4 out of 5 stars |
| Best Sellers Rank | #272 in Pet Supplies (See Top 100 in Pet Supplies) #4 in Dog Flea Drops |
| Item model number | 74273 |
| Active Ingredients | Fipronil 9.8% & (S)-methoprene 8.8%. |
| Product Dimensions | 5.75 x 0.75 x 4.5 inches; 0.16 ounces |
| Included Components | Package includes 3 applicators |
| Allergen Information | Allergen-Free |
| Date First Available | October 2, 2001 |
| Warranty Description | If you are not satisfied with FRONTLINE Plus for any reason, please contact the Boehringer-Ingelheim Animal Health Customer Care Team at: 1-800-660-1842 |
| Age Range Description | All Life Stages |
| Age Range (Description) | All Life Stages |
| Manufacturer Part Number | P004FLTSP-0-22 |
| Manufacturer recommended age | 1 month and up |
| Is Discontinued By Manufacturer | No |
| Global Trade Identification Number | 00350604287001 |